منابع مشابه
Execution of RIPK3-regulated necrosis
Necroptosis is a form of regulated necrotic cell death that is mediated by receptor-interacting protein 1 (RIP1) and RIP3 kinases. Diverse receptors, including death receptors, Toll-like receptors, interferon receptors, and DAI DNA receptors are able to trigger necroptosis. The newly identified MLKL protein functions downstream of RIP1/RIP3 and is essential for the execution of necroptosis. Stu...
متن کاملRIPK1-RIPK3-MLKL-dependent necrosis promotes the aging of mouse male reproductive system
A pair of kinases, RIPK1 and RIPK3, as well as the RIPK3 substrate MLKL cause a form of programmed necrotic cell death in mammals termed necroptosis. We report here that male reproductive organs of both Ripk3- and Mlkl-knockout mice retain 'youthful' morphology and function into advanced age, while those of age-matched wild-type mice deteriorate. The RIPK3 phosphorylation of MLKL, the activatio...
متن کاملAntitumor activity of HPA3P through RIPK3-dependent regulated necrotic cell death in colon cancer
The antimicrobial peptide HPA3 shows anticancer activity in gastric cancer and leukaemia. However, how HPA3 exerts its anticancer activity, as well as whether it also exhibits activity in other cancers, remains unknown. Therefore, the aim of this study was to evaluate the anticancer activity of HPA3 and its analogues in colon cancer and to elucidate the mechanisms responsible for this activity....
متن کاملBack to the roots of regulated necrosis
In recent years, our knowledge of how cells die by regulated pathways of necrosis has increased tremendously. In this issue, Distéfano et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201605110) provide yet another milestone in our understanding of regulated necrosis as they identify a ferroptosis-like cell death in Arabidopsis thaliana.
متن کاملPyroptosis as a Regulated Form of Necrosis
Pyroptosis is characterized by pore formation in the plasma membrane, cell swelling, and membrane disruption. These cellular events are also noted in necrosis, but not apoptosis, which is defined as a mode of regulated or programmed necrosis. Jorgensen et al have defined pyroptosis by the following 4 criteria: (1) programmed by an inflammatory caspase activation, (2) pore formation in the plasm...
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ژورنال
عنوان ژورنال: Molecular & Cellular Oncology
سال: 2014
ISSN: 2372-3556
DOI: 10.4161/23723548.2014.960759